health

Treatment of mild, chronic hypertension during pregnancy leads to favorable outcomes

Treatment of mild and chronic hypertension during pregnancy yields positive results

In pregnant women with mild and chronic hypertension, a treatment strategy aimed at lowering blood pressure below 140/90 mmHg was associated with better pregnancy outcomes than a strategy that treated only severe hypertension without compromising fetal growth.

This is what researchers from the United States wrote in the New England Journal of Medicine. They conducted a randomized, open-label, multicenter trial in which a total of 2,408 pregnant women with one child, gestational age of less than 23 weeks with moderate and chronic hypertension (<160/100 mmHg) were randomized to antihypertensive drugs (recommended tags for use during pregnancy), or without treatment (unless severe hypertension occurs).

The primary outcome was a composite measure of pre-eclampsia with severe symptoms, medically indicated preterm birth (<35 weeks’ gestation), placental abruption, and fetal or neonatal death. This outcome was less common in the treatment group (30.2%) than in the control group (37.0%), with an adjusted hazard ratio of 0.82 (95% CI 0.74–0.92; P<0.001). The safety outcome, defined as birth weight less than the 10th percentile of gestational age, was not significantly more common in the treatment group (11.2%) than in the control group (10.4%; hazard ratio 1.04; 95% CI 0.82–1.31, p = 0.76).

Furthermore, serious maternal complications occurred in 2.1 and 2.8% (0.75; 95% CI 0.45-1.26) and serious neonatal complications in 2.0 and 2.6% (0.77 95% CI 0.45-1.30). The risk of pre-eclampsia (0.79; 95% CI 0.69-0.89) and preterm birth (0.87; 95% CI 0.77-0.99) was lower in the treated group than in the control group.

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button